NCT04715113

Blood Markers Predict Effect of Normobaric Hypoxia at Rest and During Exercise in Patients With Pulmonary Hypertension

Hemodynamic Effects of Acute Normobaric Hypoxia During Exercise in Patients With Pulmonary Hypertension: Single-center Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: University of Zurich · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

To study the effect of acute normobaric hypoxia during exercise in patients with pulmonary hypertension on blood markers (serum markers of iron and red blood cell homeostasis and micro-RNAs known to be associated with PH).

Conditions

• Hypertension, Pulmonary

Interventions

Type	Name	Description
OTHER	Normobaric hypoxia (FiO2 15%)	Inhalation of deoxygenated air through an altitude simulator ("Altitrainer"), for approx. 1/2 hour given by a facemask, first at rest and then during exercise.
OTHER	Placebo-ambient air (FiO2 21%)	Inhalation of room air through an altitude simulator ("Altitrainer"), for approx. 1/2 hour given by a facemask, first at rest and then during exercise.
OTHER	Normobaric hypoxia (FiO2 15%) under Sildenafil	Inhalation of deoxygenated air through an altitude simulator ("Altitrainer"), for approx. 1/2 hour given by a facemask, first at rest and then during exercise under Sildenafil.
OTHER	Placebo-ambient air (FiO2 21%) under Sildenafil	Inhalation of room air through an altitude simulator ("Altitrainer"), for approx. 1/2 hour given by a facemask, first at rest and then during exercise under Sildenafil.

Timeline

• Start date: 2021-02-01
• Primary completion: 2023-05-31
• Completion: 2023-05-31
• First posted: 2021-01-20
• Last updated: 2023-06-06

Locations

1 site across 1 country: Switzerland