NCT04711590

Microcirculation in Spontaneous Breathing Trial

Association Between Change of Microcirculation After Spontaneous Breathing Trial and Ventilator Weaning

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 59 (actual)
• Sponsor: National Taiwan University Hospital · Academic / Other
• Sex: All
• Age: 20 Years
• Healthy volunteers: Not accepted

Summary

Weaning ventilator support in critically ill patients is crucial. Both delayed extubation and unexpected early reintubation are harmful to the patients. Weaning parameters and spontaneous breathing trial are used to investigate the indication and predict the successful extubation. Hemodynamic stability and physical reserve are important indicators as well. Microcirculation parameters are known to be more sensitive to the change of hemodynamic status than macrocirculation parameters. We hypothesize that the change of sublingual microcirculation before and after spontaneous breathing trial is different between the the patients with successful extubation and the patients with failed extubation. Thus, this study measures sublingual microcirculation in patients receiving spontaneous breathing trial and record the extubation status (successful or failed). The microcirculation parameters before and after spontaneous breathing trial are compared between the the patients with successful extubation and the patients with failed extubation.

Conditions

• Critically Ill

Interventions

Type	Name	Description
OTHER	Microcirculation examination	Sublingual microcirculation images were recorded using an incident dark-field video microscope

Timeline

• Start date: 2019-12-05
• Primary completion: 2022-06-13
• Completion: 2022-09-30
• First posted: 2021-01-15
• Last updated: 2022-12-14

Locations

1 site across 1 country: Taiwan