NCT04711044

Investigation of a New Human Model for Itch

Characterization of New Human Models of Non-histaminergic Itch and Their Interaction With the TRPM8 Receptor

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Aalborg University · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

This third sub-project aims to evaluate the interaction between the TRPM8 receptor and pruritus by studying the anti-pruritic effect of TPRM8-agonist L-menthol on histaminergic and non-histaminergic itch induced using three different pruritogens: histamine, cowhage and papain.

Conditions

• Itch

Interventions

Type	Name	Description
OTHER	Papain	Papain will be applied using cowhage spicules inactivated by heat
OTHER	Histamine	To deliver histamine, standard allergy skin prick test (SPT) lancets are applied
OTHER	Cowhage	Cowhage spicules are 1-2 mm in length and have a diameter of 1-3 μm. The spicules are inserted by gently rubbing 30-35 spicules into a 1 cm diameter skin area.
OTHER	L-menthol	A 1 mL aliquot is dispensed onto a 2,5 × 2,5 cm cotton pad and placed on a 6 × 6 cm sheet of medical tape.

Timeline

• Start date: 2021-02-01
• Primary completion: 2021-06-30
• Completion: 2021-07-05
• First posted: 2021-01-15
• Last updated: 2021-07-09

Locations

1 site across 1 country: Denmark