NCT04710459

Endobronchial Cryotherapy in Management of MEBO in Patients With Inoperable NSCLC

The Value of Endobronchial Cryotherapy in the Management of Malignant Endobronchial Obstruction in Patients With Inoperable NSCLC: A Prospective Analysis of Clinical and Survival Outcomes

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Mohamed Abdel Bary Ahmed Ibrahim · Academic / Other
• Sex: All
• Age: 47 Years – 71 Years
• Healthy volunteers: —

Summary

Background: In end-stage patients when all management options have been used, will often develop compromise of their airways as the cancer continues to progress. Endobronchial therapy options may help to relieve some of their symptoms, allowing improvement in their shortness of breath as they go home in combination with other palliative therapies. Objective: to compare the safety ; efficacy; and clinical outcome of endobronchial cryotherapy combined with chemotherapy and/ or radiotherapy versus chemo-radiotherapy alone on patients with Non small cell lung cancer. Patients and method(s): A prospective randomized clinical trial was carried out on 60 patients with different ages of both sexes, diagnosed as bronchogenic carcinoma non-small cell lung cancer type (NSCLC) . The patients attended the hospital in the chest department, Qena Faculty of Medicine, South Valley University. Assessment of the patients was done and randomly assigned into two groups. Group1 ,Include 30 patients subjected to chemotherapy , radiotherapy and endobronchial cryotherapy.Group 2 , Include include 30 patients subjected to chemotherapy and radiotherapy alone.

Conditions

• Non Small Cell Lung Cancer
• Non-Small Cell Carcinoma of Lung, TNM Stage 4
• Bronchogenic Cancer

Interventions

Type	Name	Description
PROCEDURE	cryotherapy	Group 1 included 30 patients, they were subjected to chemoradiotherapy plus endobronchial cryotherapy. Group 2 included include 30 patients, they were subjected to chemoradiotherapy.

Timeline

• Start date: 2016-12-01
• Primary completion: 2019-04-01
• Completion: 2019-05-01
• First posted: 2021-01-14
• Last updated: 2021-03-08