NCT04710316

Study of COVID-19 Outbreak in Hospital Departments of Bamako, Mali

Étude de l'épidémie de SARS-CoV-2 Dans Les Services Hospitaliers de Bamako, Mali

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 450 (actual)
• Sponsor: Institut National de la Santé Et de la Recherche Médicale, France · Other Government
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The new coronavirus known as SARS-Cov-2 (severe acute respiratory syndrome -coronavirus 2) was first reported in December 2019 and rapidly became a public health emergency. The COVID-19 pandemic is now affecting sensitive regions with fragile health care systems, such as South America and Africa. Caregivers, in the front line of Covid19 patient management, may accidentally become infected and a source of infection during the incubation phase or in case of asymptomatic infection. The objectives of this project are thus i) to assess SARS-Cov-2 spread over the hospital departments of Bamako by carrying out a systematic molecular screening of patients and caregivers, ii) to evaluate the feasibility of Point-Of-Care molecular assays in Mali and iii) to estimate the immunity acquired from SARS-Cov-2 among health workers through serological testing, allowing also the assessment of asymptomatic caregiver rate and absence of re-infection among the immunized caregivers. Finally, iv) variability of the virus over time and spread of different variants around the world will be studied by sequencing the viral genome.

Conditions

• Covid19

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	SARS-CoV-2 screening by molecular biology	SARS-CoV-2 RT-PCR in nasopharyngeal swab targeting 2 regions of the viral genome
DIAGNOSTIC_TEST	Serological screening	Serological screening of caregivers at D0, M1, M2, M3 (anti-nucleocapsid antibodies).

Timeline

• Start date: 2021-02-15
• Primary completion: 2022-04-30
• Completion: 2022-09-30
• First posted: 2021-01-14
• Last updated: 2025-12-12

Locations

4 sites across 1 country: Mali