NCT04707118

Ntraperitoneal Thermal Perfusion Combined With Chemotherapy Versus Chemotherapy

Peritoneal Perfusion Chemotherapy Combined With Gemcitabine and Albumin Binding Paclitaxel Versus Gemcitabine and Albumin Binding Paclitaxel in the Treatment of Advanced Pancreatic Cancer With Intraperitoneal Metastasis

• Status: Unknown
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 106 (estimated)
• Sponsor: Fudan University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

In view of the existence of malignant ascites in patients with advanced pancreatic cancer, we put forward the heat abdominal cavity perfusion chemotherapy combined albumin paclitaxel and gemcitabine compared with albumin paclitaxel and gemcitabine prospective clinical study, to assess abdominal albumin hot perfusion chemotherapy combined control of ascites and taxol in improving patients' quality of life, survival, exploring the feasibility of celiac hot perfusion chemotherapy combined albumin paclitaxel and side effects.

Conditions

• Advanced Pancreatic Cancer

Interventions

Type	Name	Description
DRUG	cisplatin+Nab-paclitaxel+GEM	Laparoscopic exploration + thermal perfusion cisplatin 40 mg/m2, Postoperative exploration D1, 8 Nab-paclitaxel 125 mg/m2, GEM 1000 mg/m2, D1, 8, 15 after the second thermal perfusion 4 weeks plan, 6 cycles
DRUG	Nab-paclitaxel+GEM	Nab-paclitaxel 125 mg/m2, GEM 1000 mg/m2, D1, 8, 15 4 weeks plan, 6 cycles

Timeline

• Start date: 2021-02-23
• Primary completion: 2021-12-30
• Completion: 2022-12-30
• First posted: 2021-01-13
• Last updated: 2021-01-13

Locations

1 site across 1 country: China