NCT04706000

Autophagy Markers in Endometrial Polyps

Investigation of Autophagy Markers in Endometrial Polyps

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 30 (actual)
• Sponsor: Muğla Sıtkı Koçman University · Academic / Other
• Sex: Female
• Age: 35 Years
• Healthy volunteers: Accepted

Summary

The aim of this research is to evaluate autophagy markers in patients with endometrial polyps

Detailed description

Endometrial polyp are benign formations that are frequently encountered in gynecology practice and have malignant potential. It may be asymptomatic in the clinic or may present with abnormal uterine bleeding. Although its pathophysiology has not been clearly revealed, there are many studies in the literature about it. However, the autophagy pathway emerges as a subject that has never been evaluated. In this study, the investigators would like to prospectively evaluate Beclin 1, LC3A / B and p62 markers in the autophagy pathway in endometrial polyp tissue samples by immunohistochemistry and reveal their importance.

Conditions

• Endometrial Polyp
• Autophagy

Interventions

Type	Name	Description
GENETIC	Beclin 1 gene	The determination of Beclin 1, LC3-II and p62 genes, which are evaluated by immunohistochemistry, at the protein level will be done by ELISA method in MSKU Medical Faculty Medical Biology Laboratory.

Timeline

• Start date: 2021-01-08
• Primary completion: 2022-01-08
• Completion: 2022-02-01
• First posted: 2021-01-12
• Last updated: 2023-12-06

Locations

1 site across 1 country: Turkey (Türkiye)