NCT04705909

Efficacy of Statin Addition to Neoadjuvant Chemotherapy Protocols for Breast Cancer

• Status: Unknown
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Mansoura University · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Different modalities for breast cancer treatments have exhausting and distressing side effects and toxicities leading to decreased compliance. Thus, repurposing drugs with accepted safety profile and possible antitumor activity becomes an eminent constraint. Statins have been reported to have possible advantages as anticancer, and control of cancer progression. Moreover, they can sensitize cancer cells for radiotherapy. Therefore, the investigators aim to investigate the effect of (pitavastatin) added to conventional chemotherapy protocols for breast cancer patients.

Conditions

• Breast Cancer

Interventions

Type	Name	Description
DRUG	Pitavastatin	Pitavastatin 2 mg oral tablets daily will be given to the patients concomitantly with the intended chemotherapy protocol for the treatment period prior to surgery.
DRUG	placebo	patients in this group will receive placebo tablets concomitantly with the intended chemotherapy for the treatment period prior to surgery.

Timeline

• Start date: 2021-01-15
• Primary completion: 2021-09-15
• Completion: 2021-12-15
• First posted: 2021-01-12
• Last updated: 2021-01-12

Locations

1 site across 1 country: Egypt