NCT04705142

Beneficial Effect of Intravenous Magnesium Sulphate in Term Neonates With Hypoxic Ischemic Encephalopathy(HIE)

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 200 (actual)
• Sponsor: Services Institute of Medical Sciences, Pakistan · Other Government
• Sex: All
• Age: 6 Hours
• Healthy volunteers: Not accepted

Summary

Neonatal mortality rate is the highest in Pakistan. And Birth Asphyxia is one of the main reversible causes. Outcomes related to birth asphyxia can be improved, if intervention done in time with proper measures. MgSO4 is cheaper and easily available drug.

Detailed description

Some studies showed positive results if given within 6 hours of birth asphyxia, whereas some are not supportive. But still less know about this drug, especially in low income countries. Objective of this study is to see beneficial effects of MgSO4 in neonates presenting with birth asphyxia.

Conditions

• HIE

Interventions

Type	Name	Description
DRUG	MgSo4	Before and during administration of MgSO4, B.P, Capillary refill time, Heart rate and respiratory rate will be assessed closely i-e on 10 minutes interval, infusion of MgSO4 will be give over 30 minutes and baby will be monitored every 15 minutes interval after completion of infusion as well for 1 hour.

Timeline

• Start date: 2019-05-01
• Primary completion: 2020-12-30
• Completion: 2020-12-30
• First posted: 2021-01-12
• Last updated: 2021-01-12

Locations

1 site across 1 country: Pakistan