NCT04704440

Effects of Normobaric Hypoxia During Exercise in Patients With Pulmonary Hypertension With/Without Sildenafil

Hemodynamic Effects of Acute Normobaric Hypoxia During Exercise in Patients With Pulmonary Hypertension: Single-center Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: University of Zurich · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

To study the effect of acute normobaric hypoxia during exercise in patients with pulmonary hypertension with/without Sildenafil

Conditions

• Hypertension, Pulmonary

Interventions

Type	Name	Description
OTHER	Normobaric hypoxia (FiO2 15%)	Inhalation of deoxygenated air through an altitude simulator ("Altitrainer"), for approx. 1/2 hour given by a facemask, first at rest and then during exercise.
OTHER	Placebo-ambient air (FiO2 21%)	Inhalation of room air through an altitude simulator ("Altitrainer"), for approx. 1/2 hour given by a facemask, first at rest and then during exercise.
OTHER	Normobaric hypoxia (FiO2 15%) under Sildenafil	Inhalation of deoxygenated air through an altitude simulator ("Altitrainer"), for approx. 1/2 hour given by a facemask, first at rest and then during exercise.
OTHER	Placebo-ambient air (FiO2 21%) under Sildenafil	Inhalation of room air through an altitude simulator ("Altitrainer"), for approx. 1/2 hour given by a facemask, first at rest and then during exercise.

Timeline

• Start date: 2021-02-01
• Primary completion: 2023-05-31
• Completion: 2023-05-31
• First posted: 2021-01-11
• Last updated: 2023-06-06

Locations

1 site across 1 country: Switzerland