NCT04701346

Sulfur Amino Acids, Energy Metabolism and Obesity

Dietary Sulfur Amino Acid Restriction, Energy Metabolism and Obesity

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 61 (actual)
• Sponsor: University of Oslo · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The primary objective of the trial is to establish the effects of dietary sulfur amino acid (SAA) restriction on body weight, body composition and energy expenditure in humans.

Detailed description

Dietary SAA restriction is an established model for increasing lifespan and improving metabolic health in animal studies. Data from human studies are limited. In this study the investigators will perform an 8-week dietary intervention with SAA restriction to characterise the effects on several parameters related to metabolic health including body weight, body composition, energy expenditure, lipid profile and gene expression profiles in adipose tissue. The aim is to translate findings from previous animal experiments to humans

Conditions

• Overweight and Obesity

Interventions

Type	Name	Description
OTHER	Low SAA diet	Diet with low content of methionine and cysteine
OTHER	High SAA diet	Diet with high content of methionine and cysteine

Timeline

• Start date: 2021-03-01
• Primary completion: 2022-03-17
• Completion: 2022-03-17
• First posted: 2021-01-08
• Last updated: 2022-05-19

Locations

1 site across 1 country: Norway