NCT04700631

Extracellular Vesicles as Biomarkers for Chronic Renal Failure

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 143 (actual)
• Sponsor: Centre Hospitalier Universitaire, Amiens · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The recent discovery of extracellular vesicles (EV) as a mechanism of intercellular communication has made it possible to develop a new field of health research and could bring new information on the pathological mechanisms of renal diseases. Definition of physiologic and pathologic values of urinary extracellular vesicles (EVu) between healthy subjects and chronic kidney diseases (CKD) patients could be a new tool for follow up of renal diseases. EV are found in all biological fluids including urine, that's why they are increasingly analyzed in renal pathologies. The main objective of this study is to determine the physiological values and the pathological thresholds of EVu.

Conditions

• Chronic Renal Failure
• Urinary Extracellular Vesicle

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	urinary extracellular vesicle concentration	urinary extracellular vesicle concentration will be determined in urine samples from CRF and healthy patients
DIAGNOSTIC_TEST	blood sample	blood sample in order to determine creatin level

Timeline

• Start date: 2021-01-01
• Primary completion: 2023-07-01
• Completion: 2023-07-01
• First posted: 2021-01-08
• Last updated: 2025-09-19

Locations

1 site across 1 country: France