NCT04700241

Nitrate and Brain Insulin-Sensitivity

Acute Effects of Inorganic Nitrate on Brain Insulin-sensitivity in Abdominally Obese Men

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 18 (actual)
• Sponsor: Maastricht University Medical Center · Academic / Other
• Sex: Male
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

Disturbances in brain insulin-sensitivity are not only observed in abdominal obesity and type 2 diabetes mellitus (T2D), but also during brain aging and in dementia. Inorganic nitrate may improve brain insulin-sensitivity, which can be quantified by measuring the gray-matter cerebral blood flow (CBF) response to intranasally administered insulin, through beneficial effects on brain vascular function. Therefore, we now hypothesize that inorganic nitrate, which can be found in several vegetables such as beetroot, improves brain insulin-sensitivity, as assessed by the gray-matter CBF response to intranasally administered insulin, in abdominally obese men.

Conditions

• Nitrate
• Brain Insulin-sensitivity
• Vascular Function

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Potassium nitrate	Acute intervention (5.5 hours)
DIETARY_SUPPLEMENT	Placebo	Acute intervention (5.5 hours)

Timeline

• Start date: 2021-01-21
• Primary completion: 2021-05-05
• Completion: 2021-05-05
• First posted: 2021-01-07
• Last updated: 2021-06-09

Locations

1 site across 1 country: Netherlands