NCT04699279

Protective Effect of Statin Against Negative Cardiovascular Remodeling and Organ Dysfunction After Acute Aortic Syndrome Surgery (PANDA III)

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 300 (estimated)
• Sponsor: Nanjing Medical University · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

Acute Aortic Syndrome (AAS)/Aortic Aneurysm is a common feature of aortic wall events, including aortic dissection, intramural hematoma, aortic ulceration and aortic trauma, and occurs in up to 35 cases per 100,000 cases per year between the ages of 65 and 75 years. Increased levels of the inflammatory biomarker high-sensitivity C-reactive protein predict cardiovascular events. Since statins lower levels of high-sensitivity C-reactive protein as well as cholesterol, the authors hypothesized that people with acute aortic syndrome but without hyperlipidemia might benefit from statin treatment.

Conditions

• Acute Aortic Syndrome
• Aortopathy

Interventions

Type	Name	Description
DRUG	Rosuvastatin 10mg	Rosuvastatin 10mg is taken by oral or nasal feeding every day at ang time.

Timeline

• Start date: 2021-01-01
• Primary completion: 2024-12-31
• Completion: 2024-12-31
• First posted: 2021-01-07
• Last updated: 2024-12-13

Locations

5 sites across 1 country: China