Trials / Unknown
UnknownNCT04695990
Study on the Clinical and Mechanism of Wenyang Huoxue Decoction in Treating Heart Failure After Myocardial Infarction
- Status
- Unknown
- Phase
- Phase 2
- Study type
- Interventional
- Enrollment
- 200 (estimated)
- Sponsor
- Jun Li · Academic / Other
- Sex
- All
- Age
- 18 Years – 75 Years
- Healthy volunteers
- Not accepted
Summary
This study is a randomized, double-blind, placebo-controlled, parallel clinical trial in a Chinese population with heart failure after myocardial infarction. The objective is to observe the efficacy and safety of Wenyang huoxue fang in the treatment of heart failure after myocardial infarction.
Detailed description
Currently, there is a lack of high-quality evidence-based support for TCM treatment of heart failure after myocardial infarction. In addition, previous studies have found that the method of warming Yang and activating blood circulation is effective in treating coronary heart disease, and the core pathogenesis of heart failure after myocardial infarction is also Yang deficiency and blood stasis. Therefore, this project aims to evaluate the clinical value of warming Yang and activating blood circulation in the treatment of heart failure after myocardial infarction. Through pharmacological research and detection, the efficacy of Wenyang huoxue prescription in heart failure rats after intervention of myocardial infarction was evaluated, mir-233-ISO signaling pathway was detected before and after treatment, and its mechanism of action was further clarified from the perspective of epigenetics and classical pathway of heart failure. Objective To investigate the efficacy and safety of Wenyang Huoxue fang in the treatment of heart failure after myocardial infarction.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Wenyang Huoxue Decoction | Wenyang Huoxue granules |
| DRUG | Wenyang Huoxue placebo | Wenyang Huoxue placebo have an identical appearance and scent as the active treatment granules. |
Timeline
- Start date
- 2021-01-15
- Primary completion
- 2022-03-01
- Completion
- 2022-12-30
- First posted
- 2021-01-06
- Last updated
- 2021-01-06
Source: ClinicalTrials.gov record NCT04695990. Inclusion in this directory is not an endorsement.