NCT04693962

FGF23 as a Marker of Acute Kidney Injury

Fibroblast Growth Factor-23 as a Marker of Acute Kidney Injury After Partial Nephrectomy

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 40 (estimated)
• Sponsor: University of Chile · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

A partial nephrectomy (PN) preserves renal parenchyma with a proper oncology outcome. PN is performed during transitory ischemia to avoid massive bleeding during tumor resection. Nevertheless, the transitory ischemia might cause an acute kidney injury(AKI). AKI diagnose is based on the increase in plasma creatinine concentration and a decrease in urine output. However, both plasma creatinine concentration and diuresis are useful for the diagnose, but not in the detection of the risk patients. Therefore, there is considerable interest to find a biomarkers of kidney injury that allow clinicians to predict the development of AKI. Hence, we propose Fibroblastic Growth Factor-23 (FGF23) as a novel early biomarker to detect patients in risk to develop postoperative AKI after a PN. We will conduct an observational and prospective study in three different groups of patients: PN gropup, patients who underwent PN with a transient and controlled renal ischemia injury using a renal artery clamping; Hemicolectomy (HC) group, patients as non-renal ischemia surgery controls, with similar demographic characteristics, but submitted to HC; and Nephrolithotomy (NL) group, patients who underwent NL, as a control of kidney surgery with physical injury. In each patient, a time curve of plasmatic creatinine, blood urea nitrogen (BUN), and FGF23 were measure. Our study aims to describe the role of FGF23 as an early biomarker of AKI after PN, where patients are exposed to a controlled ischemic injury.

Conditions

• Acute Kidney Injury
• Kidney Ischemia

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Plasmatic Fibroblast Growth Factor-23 by means of ELISA	Plasma levels of FGF-23 will be measured by ELISA

Timeline

• Start date: 2017-04-01
• Primary completion: 2020-05-30
• Completion: 2021-12-01
• First posted: 2021-01-05
• Last updated: 2021-01-05

Locations

1 site across 1 country: Chile