NCT04690660

Swiss Postpartum Hypertension Cohort

Swiss Postpartum Hypertension Cohort (Swiss-PPHT)

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 480 (estimated)
• Sponsor: University Hospital, Basel, Switzerland · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This open label, prospective observational, single-center registry is to study short-, intermediate-and long-term course of postpartum hypertension and predictors/risk factors associated with long term cardiovascular and renal risk. Current disease management strategies will be evaluated.

Conditions

• Postpartum Hypertension (PPHT)

Interventions

Type	Name	Description
OTHER	Data collection for parameters of organ damage (cardiac and renal blood markers)	Blood results will be taken out of next routine venipuncture. Routinely collected standard parameters are a blood count, chemistry panel including renal parameters and electrolytes, lipid profile and a HbA1c as well as albumin/creatinine and protein/creatinine ratio in urine.
OTHER	Data collection for blood pressure (BP)	Clinic blood pressure and 24hour BP Measurements
OTHER	Home-based blood pressure management (substudy)	Subjects participating in home-based blood pressure management via telemonitoring will receive a free HekaHealth application (App) for the structured assessment of HBPM.
OTHER	Biomarker Profiles (substudy)	Substudy where possible cardiac, renal and pregnancy related biomarkers will be additionally analyzed. The following biomarkers will be analyzed: N terminal (NT)-proBNP, Troponin, elevated mid-regional pro-atrial natriuretic peptide (ANP), elevated mid-regional pro adrenomedullin (ADM), soluble fms-like tyrosine kinase (sFlt-1), and placenta growth factor (PlGF).
OTHER	Data collection on patient reported outcomes	Data collection on patient reported outcomes (Questionnaire EQ-5D, Questionnaire for App based monitoring )

Timeline

• Start date: 2020-06-04
• Primary completion: 2030-05-01
• Completion: 2030-05-01
• First posted: 2020-12-31
• Last updated: 2025-05-28

Locations

1 site across 1 country: Switzerland