NCT04688736

Efficacy of Placebo Versus Chlorpheniramine for the Prevention of Allergic Transfusion Reactions.

A Prospective, Randomized, Double-blind Controlled Trial of Chlorpheniramine Pretransfusion Medication for Allergic Transfusion Reactions

• Status: Recruiting
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 6,642 (estimated)
• Sponsor: Institute of Hematology & Blood Diseases Hospital, China · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This is a prospective, randomized, double-blind controlled trial to evaluate the efficacy of placebo versus chlorpheniramine for the prevention of allergic transfusion reactions.

Conditions

• Allergic Transfusion Reaction

Interventions

Type	Name	Description
DRUG	Placebo	The tablet resembles chlorpheniramine but has no therapeutic value.
DRUG	Chlorpheniramine	An antihistamine that reduces the natural chemical histamine in the body.

Timeline

• Start date: 2021-01-01
• Primary completion: 2026-12-31
• Completion: 2027-06-30
• First posted: 2020-12-30
• Last updated: 2025-08-05

Locations

4 sites across 1 country: China