NCT04686734

Long-term Effects of COVID-19 in Adolescents

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 516 (actual)
• Sponsor: University Hospital, Akershus · Academic / Other
• Sex: All
• Age: 12 Years – 25 Years
• Healthy volunteers: Not accepted

Summary

The overarching objective for this prospective cohort study of COVID-19 in adolescents is to study the long-term effects, with particular emphasis on post-infectious chronic fatigue. A total of 500 individuals with a SARS-CoV-2 positive test will be enrolled in the acute phase of COVID-19 and followed for 6 months. A total of 100 individuals with SARS-CoV-2 negative test will be included during the same time period as a control group. Investigations include autonomic, pulmonary and cognitive assessement; a questionnaire charting symptoms, emotionality, personality, loneliness, life events and demographics; and extensive biobanking including genetic markers, viable PBMC, urine, feces and hair. A subgroup of 40 SARS-CoV-2 positive and 20 SARS-CoV-2 negative individuals will also undergo detailed cardiological examination by echocardiography. Primary endpoints are fatigue at 6 months as assessed by the Chalder Fatigue Scale and post-COVID-19 syndrome cases at 6 months according to the WHO definition

Conditions

• Covid19

Interventions

Type	Name	Description
OTHER	No active intervention (observational only)	No active intervention (observational only)

Timeline

• Start date: 2021-01-06
• Primary completion: 2022-02-02
• Completion: 2022-06-24
• First posted: 2020-12-29
• Last updated: 2022-07-25

Locations

1 site across 1 country: Norway