NCT04685278

Anticardiolipin Autoantibodies and Mortality in Septic Patients

Anticardiolipin Autoantibodies as Useful Biomarker for the Prediction of Mortality in Septic Patients

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 50 (estimated)
• Sponsor: Military Hospital of Tunis · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The detection of antiphospholipid antibodies (aPL) is of interest because of their importance in the pathogenesis of arterial or venous thrombosis and their responsibility for a wide spectrum of clinical manifestations such as infection. The aim of the study was to assess the performance of antiphospholipid antibodies biomarker to predict in- hospital mortality in intensive care unit (ICU) septic patient's.

Detailed description

the investigators conducted a prospective single-center observational study including consecutive critically ill septic adults admitted to the intensive care unit. Clinical and laboratory data including chemiluminescence immunoassay for antiphospholipid antibodies \[anticardiolipin (aCL), antiphosphatidylserine (aPS)\] were obtained. Blood samples were collected on days 1, 3, 5, 8 and 10 of hospitalization. The primary study endpoint was ICU mortality defined as death before ICU discharge. Secondary end points included correlation between SOFA score and biological parameters.

Conditions

• Morality

Interventions

Type	Name	Description
BIOLOGICAL	Blood samples	Blood samples were collected in dry tubes on days 1, 3, 5, 8 and 10 of hospitalization

Timeline

• Start date: 2020-10-01
• Primary completion: 2021-02-05
• Completion: 2021-02-15
• First posted: 2020-12-28
• Last updated: 2020-12-28

Locations

1 site across 1 country: Tunisia