NCT04684134

High-Risk Factors in Patients With Colorectal Polyps a Prospective Case-Control Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 2,800 (actual)
• Sponsor: The First Affiliated Hospital with Nanjing Medical University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

This prospective case-control study aimed to analyze and summarize the high-risk factors and susceptible genes of patients with colorectal polyps. According to these high-risk factors, the investigators developed and validated a prediction model for colorectal polyps to identify high-risk individuals, in order to provide clinical basis for the etiology research and the establishment of effective preventive measures.

Detailed description

A large cohort of eligible participants were included in the analysis, and classified into derivation and validation cohorts at a ratio of 7:3. Demographic and clinicopathological characteristics of participants were utilized to develop a prediction model for colorectal polyps. In the derivation cohort, the LASSO regression method was applied to filter variables and select the most useful high-risk factors. Multivariate logistic regression analysis was used to identify potential predictors and then a prediction model was established. The predictive performance of the model was evaluated with respect to its discrimination, calibration and clinical usefulness.

Conditions

• Colorectal Polyp

Timeline

• Start date: 2019-06-01
• Primary completion: 2020-05-01
• Completion: 2020-06-01
• First posted: 2020-12-24
• Last updated: 2020-12-24

Locations

1 site across 1 country: China