NCT04682782

Intraoperative Small-dose Esketamine Infusion for Pain Control in Burn Patients

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 26 (estimated)
• Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study aim to determine whether a small-dose esketamine infusion can be used for pain control in severe burn patients, and thereby reduce the total intra-operative opioid requirement. Secondary objectives are to determine whether this low-dose esketamine infusion will increase the stability of circulation.

Conditions

• Burns

Interventions

Type	Name	Description
DRUG	Esketamine	Esketamine is infused through the whole period of surgery. Participants randomized to the esketamine arm will receive 1 mg/ml solution infused at 0.1 mg/kg/hour (0.1 ml/kg/h) .
DRUG	Saline	Participants randomized to the placebo arm will receive 0.9 mg/ml sodium chloride, infused at a rate of 0.1 ml/kg/hour throughout the surgery.

Timeline

• Start date: 2020-07-14
• Primary completion: 2020-12-30
• Completion: 2020-12-30
• First posted: 2020-12-24
• Last updated: 2020-12-24

Locations

1 site across 1 country: China