NCT04681586

Bright Light Therapy as Possible Treatment Option for MS-Fatigue

Bright Light Therapy as Possible Treatment Option for Fatigue in Multiple Sclerosis Patients - A Randomised Controlled Trial

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 36 (estimated)
• Sponsor: Medical University of Vienna · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This study aims to investigate the effect of a 2-week trial of bright light therapy (BLT, 10.000 lx) on fatigue in multiple sclerosis (MS) patients. In this randomised placebo-controlled trial, the effect of bright light therapy will be compared to dim red light. MS-fatigue is quantified by patients using a visual analogue scale (VAS) and activity levels, subjective and objective sleep parameters and daytime sleepiness are measured.

Detailed description

Materials and methods: * visual analogue scale (4x/day for 6 weeks; measuring fatigue) * wrist actigraphy (6 weeks) * sleep diaries (6 weeks) * polysomnography (2x) * multiple sleep latency test (2x) * 4 subtests of the TAP (Testbatterie zur Aufmerksamkeitsprüfung; Alertness, Vigilance, Go/No-Go, Split Attention) * questionnaires (Fatigue Severity Scale, Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, Beck Depression Inventory, Beck Anxiety Inventory, Modified Fatigue Impact Scale, Morningness-Eveningness Questionnaire)

Conditions

• Multiple Sclerosis
• Fatigue

Interventions

Type	Name	Description
DEVICE	bright light therapy	using a bright light therapy device (10.000 lux) for 30min every morning for two weeks
DEVICE	dim red light	using the same device as the active group, but with an installed filter that dims light to \<300 lux for 30min every morning for two weeks

Timeline

• Start date: 2019-12-01
• Primary completion: 2021-09-01
• Completion: 2022-01-01
• First posted: 2020-12-23
• Last updated: 2020-12-23

Locations

1 site across 1 country: Austria