NCT04681508

MINS, AKI and Pulmonary Pathology in Patients Undergoing Acute Abdominal Surgery

Myocardial Injury After Non-cardiac Surgery (MINS), Acute Kidney Injury (AKI) and Pulmonary Pathology in Patients Undergoing Acute Abdominal Surgery

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 600 (estimated)
• Sponsor: Nordsjaellands Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Explorative study to investigate potential predictors of myocardial injury, acute kidney injury and pulmonary disorder after acute high-risk abdominal surgery.

Detailed description

The main issues are: * To investigate if coronary calcification predisposes the development of myocardial injury and causes an increased mortality rate. * To evaluate the predictive value of NT-pro-BNP in relation to the development of MINS and the mortality rate. * To evaluate the predictive value of different biomarkers of AKI in relation to which patients develop AKI. * To examine the proteins, exosomes and single cell RNA during acute kidney injury in order to describe the molecular processes in the kidney during AKI. * To examine whether a chest CT scan without contrast enhancement will change treatment decisions in the acute gastrointestinal patient compared with a chest x-ray.

Conditions

• Abdomen, Acute
• Myocardial Injury
• Acute Kidney Injury
• Pulmonary Disease

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Chest CT without contrast enhancement and chest X-ray	Chest CT without contrast enhancement and chest X-ray as supplement to diagnostic abdominal CT

Timeline

• Start date: 2021-03-01
• Primary completion: 2025-07-31
• Completion: 2026-12-31
• First posted: 2020-12-23
• Last updated: 2023-08-21

Locations

1 site across 1 country: Denmark