NCT04680494

Effect of Acute Physical Exercise on Memory

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 25 (actual)
• Sponsor: University of Geneva, Switzerland · Academic / Other
• Sex: Male
• Age: 18 Years – 38 Years
• Healthy volunteers: Accepted

Summary

An increasing amount of studies show the beneficial effect of regular exercise on cognitive and brain functions and especially in the memory domain. Yet little is known of what happens within an acute bout of exercise and whether it would also yield cognitive effects. The literature clearly shows that molecules such as brain derived neurotrophic factor (BDNF) and endocannabinoids (mainly anandamide, AEA) are heavily involved in neural plasticity mechanisms and increase when we exercise hinting at possible mechanisms underlying memory improvement after exercise. This protocol assesses the effects of acute exercise on associative and motor sequence memory, their underlying neural activations (measured using fMRI) and blood biomarkers (BDNF and AEA). A related aim is to assess the effect of exercise intensity, therefore three exercising conditions (rest, moderate intensity and high intensity) were included. Finally, a 3-month delayed retest visit is also realized to assess effects of acute exercise on long-term memory consolidation.

Conditions

• Acute Physical Exercise

Interventions

Type	Name	Description
OTHER	moderate intensity physical exercise
OTHER	high intensity physical exercise
OTHER	rest

Timeline

• Start date: 2015-10-09
• Primary completion: 2016-07-27
• Completion: 2016-07-27
• First posted: 2020-12-23
• Last updated: 2020-12-23