NCT04678518

Inflammatory Markers Dynamics in Response to Extra-corporeal Membrane Oxygenator Decannulation

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Hamad Medical Corporation · Industry
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Extracorporeal membrane oxygenation (ECMO) aim at providing cardiac, respiratory support, or both. The use of ECMO could be associated with systemic inflammatory response syndrome (SIRS) at the time of initiation or the time of decannulation. There is an existing evidence to state that clinical criteria of SIRS accompany decannulation. We aim at proving this relation through studying the inflammatory markers changes before and after decannulation. The investigators will study all participants who require ECMO support in the heart hospital, all patient will be subjected to clinical evaluation of the SIRS criteria plus studying the inflammatory makers that will include IL1, IL2, IL6 and TNF before and after decannulation. Participants will be divided based on the SIRS criteria into 2 groups and both groups will be compared using Chi-Square analysis (Fisher tests if small sample size) or two tailed t-test, as appropriate

Conditions

• Inflammatory Markers Changes in Response to Extra-corporeal Membrane Oxygenator Decannulation

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Inflammatory makers that will include Interleukins (IL); IL1, IL2, IL6 and TNF	1 hour before decannulation and 3 times after decannulation (1 hours, 12 hours and 24 hours)

Timeline

• Start date: 2023-02-28
• Primary completion: 2023-10-31
• Completion: 2023-12-31
• First posted: 2020-12-22
• Last updated: 2022-05-19

Locations

2 sites across 1 country: Qatar