NCT04677673

Neoadjuvant Chemotherapy Plus Surgery Versus Surgery First For Elderly Gastric Cancer Patients

• Status: Not Yet Recruiting
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 232 (estimated)
• Sponsor: BIRENDRA KUMAR SAH · Academic / Other
• Sex: All
• Age: 76 Years
• Healthy volunteers: Not accepted

Summary

The main purpose of this study is to compare the feasibility and efficacy of neoadjuvant chemotherapy (modified SOX) for elderly patients with locally advanced gastric cancer.

Detailed description

DRAGON SENILE research, Neoadjuvant Chemotherapy plus Surgery versus surgery first for elderly Gastric Cancer patients, is an investigator-initiated; phase II/III, open-label, randomized controlled study. The main purpose of this study is to compare the feasibility and efficacy of neoadjuvant chemotherapy (modified SOX) for elderly patients with locally advanced gastric cancer.

Conditions

• Gastric Cancer
• Chemotherapy Effect
• Elderly Patients
• Surgery

Interventions

Type	Name	Description
DRUG	Chemotherapy	Modified SOX Chemotherapy regimen A cycle consists of Day 1: Oxaliplatin 100mg/M2 intravenous Day 1-14 Tegafur gimeracil oteracil potassium capsule 60mg/M2 oral (twice daily) Repeated every 22nd day
PROCEDURE	Curative gastrectomy	Radical gastrectomy with D2 lymph node dissection

Timeline

• Start date: 2021-01-01
• Primary completion: 2022-01-01
• Completion: 2027-01-01
• First posted: 2020-12-21
• Last updated: 2020-12-21