NCT04677426

129Xe Gas Exchange Imaging in IPF and cHP: A Reliability Study

• Status: Withdrawn
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: University of Kansas Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This research is a study to test the reliability of Hyperpolarized Xenon MRI (HXe MRI) as a biomarker in interstitial lung disease. The study is a non-randomized study to evaluate the test-retest performance of HXe MRI in Idiopathic Pulmonary Fibrosis (IPF) and chronic Hypersensitivity Pneumonitis (cHP) as a non-invasive biomarker of disease severity and prognosis. The study will include approximately 15 subjects with IPF, 15 subjects with cHP and 10 sex and age-matched normal controls performed across 3 sites.

Conditions

• Idiopathic Pulmonary Fibrosis
• Hypersensitivity Pneumonitis

Interventions

Type	Name	Description
DRUG	Hyperpolarized Xe129	Whether magnetic resonance imaging (MRI) using inhaled hyper-polarized 129 Xenon gas can help visualize impaired lung function to assess patients with cHP and IPF.

Timeline

• Start date: 2022-05-01
• Primary completion: 2022-08-01
• Completion: 2022-08-01
• First posted: 2020-12-21
• Last updated: 2022-09-10

Regulatory

• FDA-regulated drug study