NCT04673877

Vancomycin Tissue Concentrations by Bier Block or Intravenous Administration

Tissue Concentrations of Vancomycin Achieved With Bier Block Administration Versus Intravenous Prophylaxis in Upper Extremity Surgery: A Randomized Controlled Trial

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Mayo Clinic · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine whether or not giving a lower dose of antibiotics (Vancomycin) in the area where it is needed (upper extremity) is more effective at preventing infection than the current standard dose which is given intravenously (IV).

Conditions

• Infection
• Hand Injury Wrist
• Hand Injuries
• Hand Injuries and Disorders
• Hand Arthritis

Interventions

Type	Name	Description
DRUG	Systemic IV Vancomycin	1 g of vancomycin will be delivered intravenously over a period of one hour prior to tourniquet inflation.
PROCEDURE	Bier Block	After exsanguination of the limb and elevation of the tourniquet in the prepped and draped patient, Vancomycin will be injected into a superficial vein in the hand, wrist or forearm.
DRUG	Vancomycin	500 mg diluted in 50 cc normal saline of injection into superficial vein in the hand, wrist or forearm

Timeline

• Start date: 2021-08-26
• Primary completion: 2022-08-17
• Completion: 2022-08-17
• First posted: 2020-12-17
• Last updated: 2022-10-07

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study