NCT04672707

Study on the Pharmacokinetics of Bromine Hexane Hydrochloride Tablets in Healthy Adults

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 33 (actual)
• Sponsor: Second Affiliated Hospital of Wenzhou Medical University · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

This clinical study is about increasing the dosage of bromine hexane hydrochloride to safety volume and continue to give it frequently in the new crown virus treatment could improve the efficacy.

Detailed description

The purpose is to study the pharmacokinetic characteristics and safety of bromine hexane hydrochloride in healthy adults after oral administration of bromine hexane hydrochloride tablets. Then to explore the mechanism related to the role of transmembrane serine proteases (TMPRSSs) through the study, and to provide the basis for the clinical rational administration of bromine hexane hydrochloride tablets.

Conditions

• Pharmacokinetics

Interventions

Type	Name	Description
DRUG	Bromhexine Hydrochloride Tablet	32 mg
DRUG	Bromhexine Hydrochloride Tablet	48 mg
DRUG	Bromhexine Hydrochloride Tablet	64 mg
DRUG	Bromhexine Hydrochloride Tablet	80mg

Timeline

• Start date: 2020-12-28
• Primary completion: 2024-07-02
• Completion: 2024-07-02
• First posted: 2020-12-17
• Last updated: 2025-05-16

Locations

1 site across 1 country: China