NCT04672447

Effect of 4 Weeks of Citrulline and Glutathione Supplementation on Arterial Function

Effects of 4 Weeks Supplementation With L-Citrulline and Glutathione on Arterial Function and Cardiovascular Responses in Postmenopausal Healthy Women: A Pilot Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 39 (actual)
• Sponsor: Texas Tech University · Academic / Other
• Sex: Female
• Age: 50 Years – 79 Years
• Healthy volunteers: Accepted

Summary

Examining the effects of 4 weeks of Citrulline alone or in combination with glutathione on the arterial function of postmenopausal women.

Detailed description

L-Citrulline is a non-protein amino acid and an efficient precursor of L-arginine, the substrate for endothelial nitric oxide synthesis. Glutathione is a tripeptide with antioxidant effects. Postmenopausal women will ingest 6g/d of L-Citrulline or 2g of L-Citrulline plus 200mg/d of glutathione or placebo (maltodextrin) for 4 weeks with vascular function testing prior to and after the intervention.

Conditions

• Menopause
• Cardiovascular Risk Factor

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	L-Citrulline	Four weeks of oral L-Citrulline (2 grams/day) supplementation. Supplementation will be ingested daily, half of the doses in the morning and half at night.
DIETARY_SUPPLEMENT	L-Citrulline	Four weeks of oral L-Citrulline (6 grams/day) supplementation. Supplementation will be ingested daily, half of the doses in the morning and half at night.
DIETARY_SUPPLEMENT	Placebo	Four weeks of oral placebo (6 grams/day maltodextrin) supplementation. Supplementation will be ingested daily, half of the doses in the morning and half at night.
DIETARY_SUPPLEMENT	Glutathione	Four weeks of Glutathione (200mg/day) supplementation. Supplementation will be ingested daily, half of the doses in the morning and half at night.

Timeline

• Start date: 2020-07-01
• Primary completion: 2022-04-27
• Completion: 2022-04-27
• First posted: 2020-12-17
• Last updated: 2022-10-20

Locations

1 site across 1 country: United States