NCT04669795

Osteogenic Potential of Cissus Quadrangularis Alveolar Ridge Distraction

Evaluation of Osteogenic Potential of Cissus Quadrangularis on Mandibular Alveolar Ridge Distraction

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Al-Azhar University · Academic / Other
• Sex: All
• Age: 30 Years – 55 Years
• Healthy volunteers: Accepted

Summary

Deficient alveolar mandibular ridge corrected distraction osteogenesis to facilitate dental implant placement. Patients grouped into 2 groups: one group received Cissus quadrangularis during the consolidation period, and the other group received placebo.

Detailed description

OPGs were taken immediately after distractor placement, at end of activation period, at 1st,2nd month of consolidation period, and at end of consolidation period. Change in bone height was evaluated immediately after distractor placement, at end of activation and end of consolidation periods. CBCT were taken immediately after implant installation, and 6 months later to evaluate change bone density and marginal bone level about the dental implant. histological evaluation was done by biopsy obtained, by trephine bur, from implant site during its preparation. The bone biopsy fixed in 4% formalin solution for 7 days, rinsed in water, and dehydrated in sequent phases of ethanol (70, 80, 90, and 100%) and then specimens were stained by hematoxylin- eosin for microscopic evaluation. Radiographic evaluation

Conditions

• Distraction of Bone
• Dental Implant

Interventions

Type	Name	Description
DRUG	Cissus Quadrangularis	Drug with osteogenic potential given to the patients after consolidation period. dose was two capsules once /day with meals for 6 weeks

Timeline

• Start date: 2017-04-15
• Primary completion: 2019-05-30
• Completion: 2019-08-15
• First posted: 2020-12-17
• Last updated: 2020-12-17

Locations

1 site across 1 country: Egypt