NCT04666532

S. Aureus Translocation From Skin and Nose to Periprosthetic Tissues

Staphylococcus Aureus Translocation From Skin and Nose to Periprosthetic Tissues

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 200 (actual)
• Sponsor: Rothman Institute Orthopaedics · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Surgical site infections (SSI) are a significant clinical issue that requires the use of a great amount of resources. In particular, periprosthetic joint infections (PJIs) have potentially catastrophic effects on patients' health-related quality of life, function, healthcare costs, outcomes and medical implications. National surveillance estimates may under-report the true incidence and when considering the large number of total hip (THA) and total knee arthroplasty (TKA) procedures performed each year. Patients who have a high-level of nasal bacteria have been found to have a risk of surgical site infection that is three to six times the risk compared with noncarriers and low-level carriers. The association between a patient's nasal carriage of S. aureus, specifically MRSA, and PJI has been demonstrated in a systematic review and confirmed in recent cohort studies. While this association seems to be well accepted, no mechanistic explanation has been provided for this association.

Conditions

• Staphylococcus Aureus

Timeline

• Start date: 2020-10-22
• Primary completion: 2021-12-31
• Completion: 2021-12-31
• First posted: 2020-12-14
• Last updated: 2020-12-14

Locations

1 site across 1 country: United States