NCT04665804

Effects of Creatine Supplementation as Compared to Glucosamine/Chondroitin Sulfate Supplementation in Addition to Exercise and Physical Therapy in the Management of Knee Osteoarthritis.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Foundation University Islamabad · Academic / Other
• Sex: All
• Age: 40 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Osteoarthritis (OA) is one of the most common joint disorders, affecting not only the joints but also the surrounding muscles, which become weak. Resistance exercise reduces pain and improves function in patients with OA of the knee. Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used by patients with OA to reduce pain and thereby maintain the ability to perform daily activities. However, there is accumulating evidence for a negative effect of NSAIDs, thus many patients with OA are treated with dietary supplementations such as glucosamine and chondroitin sulfate, and some studies show a beneficial effects on cartilage and pain. However, their effect on OA symptoms and cartilage remains controversial. On the other hand creatine supplementation has also been observed to show promising effects when combined with resistance training exercise in the elderly, but the evidence is limited in terms of knee osteoarthritis. For this reason the purpose of this study is to determine the effects of creatine supplementation as compared to glucosamine/chondroitin sulfate in the management of knee osteoarthritis when combined with resistance training exercise.

Conditions

• Knee Osteoarthritis

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Creatine Supplementation	Creatine Supplementation 20g/day for 1 week followed by 5 g/day for 3 weeks
DIETARY_SUPPLEMENT	Glucosamine and Chondroitin sulfate supplementation	Glucosamine 500 mg Chondroitin sulfate sodium 400mg 3/day
OTHER	Supervised Exercise training	Lower Extremity Resistance Exercise Training Treadmill walking 5-10 min for warm up Strength training: (80% of 8RM) 3 times supervised exercise for 4 weeks leg press, leg extension, Sit to stand squat (mini squats) Stationary Cycling (Maximum Resistance as per patient tolerance till failure) 3 sets 8 reps 10-15 s rep rest interval 1-2 min set rest interval
OTHER	Home Exercise Program	2 sets of 10 repetitions/day of AROM isolated knee extension and knee flexion Isometric isolated knee extension and knee flexion Isometric terminal knee extension Sit to stand squat Isometric knee terminal extension
PROCEDURE	Electrotherapy + Heating	Interferential Current therapy (2P), in combination with heating pad for 20 minutes
PROCEDURE	Joint Mobilization	Tibio-femoral Anterior Glide Tibio-femoral Posterior Glide Patellofemoral Joint Mobilization

Timeline

• Start date: 2020-06-10
• Primary completion: 2020-12-06
• Completion: 2020-12-06
• First posted: 2020-12-14
• Last updated: 2020-12-14

Locations

1 site across 1 country: Pakistan