NCT04660877

Blood and Muscle Response to Cheddar Cheese in Healthy Adults

Anabolic Effects of Cheddar Cheese Consumption in Human Skeletal Muscle

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 42 (actual)
• Sponsor: University of Utah · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

The goal of this project is to use a cross over design in young healthy male and female adults: 1. To determine the amino acid blood response to the acute ingestion of cheddar cheese in comparison to that of milk. 2. To determine the muscle mTORC1 response to the acute ingestion of cheddar cheese in comparison to that of milk.

Detailed description

Each subject will take part in two metabolic studies. Each metabolic study was designed to test the acute blood and muscle response to an ingested amount of either cheddar cheese or milk. Approximately, one month after the first experiment (Metabolic Study #1), the participant will complete the second experiment (Metabolic Study #2) which was exact in design and at the same time of day as the first study but the participant ingested the alternate food product. The morning of the metabolic studies, the participant will arrive at the clinical research center after a 10h fast. A catheter will be placed in the participants' arm for blood sampling. Next, the participant will undergo a fasted thigh skeletal muscle biopsy. Following the muscle biopsy, the participant will consume either cheddar cheese (65g) or milk (370 mL) each amounting to 20g of protein. Subsequent muscle biopsies will occur at 60 and 180min after product ingestion. Blood sampling will occur in the fasted state and periodically after ingestion of the products (up to 300min).

Conditions

• Healthy

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Cheddar Cheese	20g of protein from cheddar cheese
DIETARY_SUPPLEMENT	Milk	20g of protein from milk

Timeline

• Start date: 2018-06-28
• Primary completion: 2019-08-20
• Completion: 2019-08-20
• First posted: 2020-12-09
• Last updated: 2022-06-22

Locations

1 site across 1 country: United States