NCT04658524

Evaluation of Thyroid Function in Patients With Chronic Kidney Disease

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 44 (estimated)
• Sponsor: Rio de Janeiro State University · Academic / Other
• Sex: All
• Age: 18 Years – 100 Years
• Healthy volunteers: —

Summary

A higher prevalence of thyroid disease has been associated with chronic kidney disease (CKD), and subclinical hypothyroidism seems to be the most common dysfunction. The aim is to evaluate thyroid function and autoimmunity in patients with CKD stages 3, 4 and 5. Cross-sectional study to be carried out on patients with stages 3 and 4 in a Nephrology outpatient clinic. Thyroid function is evaluated by measuring thyroid stimulating hormone (TSH), free thyroxine, free triiodothyronine and antithyroperoxidase antibodies (TPOAb) levels.

Detailed description

Cross-sectional study to be carried out on patients with stages 3, 4 and 5 in a Nephrology outpatient clinic. Thyroid function is evaluated by measuring thyroid stimulating hormone (TSH), free thyroxine, free triiodothyronine and antithyroperoxidase antibodies (TPOAb) levels. Free Thyroxine (FT4) will be measured by liquid chromatography tandem mass spectrometry and electrochemiluminescence immunoassay in order to compare methods in this population. The glomerular filtration rate was estimated (eGFR) by the Chronic Kidney Disease Epidemiology Collaboration formula (CKD-EPI), and the CKD stages were defined according to the Kidney Disease Improving Global Outcomes directives (KDIGO).

Conditions

• Chronic Kidney Disease
• Thyroid Dysfunction

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Thyroid function	laboratorial thyroid tests

Timeline

• Start date: 2018-07-01
• Primary completion: 2019-11-30
• Completion: 2025-12-30
• First posted: 2020-12-08
• Last updated: 2020-12-09

Locations

1 site across 1 country: Brazil