NCT04656314

Renal Functional Magnetic Resonance Imaging in Healthy Persons - Reproducibility and Impact of Stress

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 20 (actual)
• Sponsor: University of Aarhus · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The main purpose of the study is to describe the applicability and reproducibility of functional MRI scans of the kidneys in healthy participants. Furthermore, the study examines to what extent physiological stress caused by lying in a scanner affects the renal perfusion and thus the reproducibility

Detailed description

2 groups of 10 healthy participants each are included. 1 group aged 18 to 40 and a group of participants above 60 years of age. The functional MRI sequences are performed consecutively in a protocol set up on a 1,5 T MRI scanner. In totl, 3 identical scans are being performed. 2 scans on day 1 followed by another scan 1-2 weeks later. Before and after each scan, cortisol and copeptin is controlled in a blood sample to quantify the level of physiological stress.

Conditions

• Healthy

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Functional MRI scan	Functional MRI scan: Phase contrast, BOLD, Arterial Spin Labeling, Diffusion weighted MRI, T1 mapping, T1rho mapping

Timeline

• Start date: 2021-01-15
• Primary completion: 2021-03-27
• Completion: 2021-03-27
• First posted: 2020-12-07
• Last updated: 2021-04-08

Locations

1 site across 1 country: Denmark