NCT04656210

Myotonic Dystrophy - Vascular and Cognition

Links Between Diabetes and Cognitive Impairment in Myotonic Dystrophy Type 1 : a Non-conventional MRI Study

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 85 (actual)
• Sponsor: University Hospital, Lille · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The cognitive disorders of adult forms of myotonic dystrophies type 1 are heterogeneous (impairment of executive functions, visio construction and theory of the mind, which can progress to the stage of dementia). Nevertheless, patients have very different degrees of cognitive impairment. Expansion of CTG triplets disrupts the alternative splicing of mRNAs of various proteins, including the insulin receptor and Tau protein. Type 2 diabetes, associated with peripheral insulin resistance, is therefore common in this pathology. Type 2 diabetes,could to explain the cognitive impairment of patients, through the accelerated development of brain lesions (especially tauopathy and cerebral atrophy).

Conditions

• Myotonic Dystrophy 1
• Diabetes
• Carbohydrate Intolerance

Interventions

Type	Name	Description
RADIATION	MRI	Non conventional MRI (35 minutes)
OTHER	neuropsychological tests	Standardized and quantified neuropsychological assessment

Timeline

• Start date: 2021-10-14
• Primary completion: 2024-10-13
• Completion: 2029-01-01
• First posted: 2020-12-07
• Last updated: 2025-05-23

Locations

1 site across 1 country: France