NCT04655378

Validation of the IgA1 Detection Method With Gradient Glycosylation by Mass Spectrometry as a Potential Marker of Renal Involvement in Pediatric Rheumatoid Purpura

Recherche d'un Marqueur Pronostique de l'Atteinte rénale du Purpura Rhumatoïde de l'Enfant. Validation de la méthode de détection Des IgA1 Avec Gradient de la Glycosylation Par spectrométrie de Masse

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 52 (actual)
• Sponsor: Centre Hospitalier Universitaire de Nīmes · Academic / Other
• Sex: All
• Age: 3 Years – 16 Years
• Healthy volunteers: Accepted

Summary

In this ancillary study on the FoxTreg cohort, the study investigators will select variables to input and thus develop two models (Linear Discriminant Analysis and Decision Tree). The aim of this study is to validate the method in terms of repeatability, reproducibility, control of pre-analytical conditions and sample conservation, to complete the screening of IgA glycosylation in individuals of the FoxTreg cohort and to refine the glycopeptide signature to predict renal involvement.

Conditions

• Rheumatoid Purpura
• Pediatric ALL

Interventions

Type	Name	Description
OTHER	Mass Sepctrometry	Mass spectrometry (LC/MS) of purified immunoglobulins

Timeline

• Start date: 2020-10-22
• Primary completion: 2021-12-31
• Completion: 2022-12-31
• First posted: 2020-12-07
• Last updated: 2023-02-08

Locations

2 sites across 1 country: France