NCT04654221

Evaluation of Renal Function in Subjects Who Had Undergone Cardiac Surgery

Evaluation of eGFR, Determined by Cystatin C and Creatinine, and mGFR, Measured by Iohexol Clearance, in Subjects at High Risk for Acute Kidney Injury (AKI) Following Cardiac Surgery

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 16 (actual)
• Sponsor: Quark Pharmaceuticals · Industry
• Sex: All
• Age: 45 Years
• Healthy volunteers: Not accepted

Summary

To evaluate the differences between serum cystatin C based estimated glomerular filtration rate (eGFRcys), serum creatinine based eGFR (eGFRcreat) and measured glomerular filtration rate (mGFR) in subjects at high risk for acute kidney injury (AKI) approximately 90 days following cardiac surgery

Detailed description

This is an open label, single-visit study to evaluate the relationship between mGFR and eGFR based either on serum creatinine (eGFRcreat) or cystatin C (eGFRcys) approximately 90 days following cardiac surgery. No investigational study drug will be administered.

Conditions

• Cardiac Surgery

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	mGFR by iohexol clearance	Iohexol 5mL injection (300 mg iodine/mL) will be administered to all subjects to determine mGFR by iohexol clearance

Timeline

• Start date: 2020-02-21
• Primary completion: 2021-02-25
• Completion: 2021-03-26
• First posted: 2020-12-04
• Last updated: 2021-07-16

Locations

6 sites across 1 country: United States