NCT04653792

Role Of Pregabalin To Decrease Postoperative Pain In Microdiscectomy

Role Of Pregabalin To Decrease Postoperative Pain In Microdiscectomy: A Randomized Clinical Trial

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 84 (actual)
• Sponsor: Ziauddin University · Academic / Other
• Sex: All
• Age: 20 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to compare the effect of pregabalin in reducing the neuropathic pain in postoperative patients who have undergone single level Microdiscectomy for prolapsed intervetebral lumbar disc.

Detailed description

All patients were informed in detailed regarding the risk and complications and given written and informed consent, coming to our clinics were assessed by one of the senior team members of the spine, patient fulfilling the eligibility criteria were selected and included in the study. One week before the surgery the patients who met the eligibility criteria were randomized in a double-blind manner (participant and investigator) in a ratio of 1:1 into Group-A (Pregabalin 7mg, twice daily) or Group-B (Placebo, twice daily). The pain scores were recorded by VAS and Roland Morris score system on preoperative day compared to the scores on the 1st week postoperative follow-up.

Conditions

• Pain, Nerve
• Prolapsed Intervertebral Disc

Interventions

Type	Name	Description
DRUG	Pregabalin 75mg	75 mg capsule
DEVICE	Placebo	75 mg

Timeline

• Start date: 2018-06-04
• Primary completion: 2020-04-17
• Completion: 2020-04-17
• First posted: 2020-12-04
• Last updated: 2020-12-04

Locations

1 site across 1 country: Pakistan

Regulatory

• FDA-regulated drug study
• FDA-regulated device study