NCT04653610

Sequential Analysis Before and After Treatment Initiation to Unravel the Role of Naturally Occurring Extracellular Vesicles in HIV Infection

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 105 (estimated)
• Sponsor: University Hospital, Ghent · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

This study aims to evaluate the role of extracellular vesicles in HIV-infection, by determining the expression profile and content of EVs before and after treatment initiation in HIV-infected patients, through extensive blood and tissue sampling (leukapheresis, stool sampling and colon biopsies). A one-time sampling (blood, stool, colon biopsies) will also be performed in HIV-seronegative healthy volunteers to confirm that results found in HIV-infected patients are related to the disease.

Conditions

• Hiv

Timeline

• Start date: 2021-01-27
• Primary completion: 2027-01-01
• Completion: 2027-01-01
• First posted: 2020-12-04
• Last updated: 2024-02-08

Locations

1 site across 1 country: Belgium