NCT04651829

Suspicion of Non IgE-mediated Cow's Milk Protein Allergy: Prevalence and Evolution

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 100 (actual)
• Sponsor: Hôpital Armand Trousseau · Academic / Other
• Sex: All
• Age: 4 Months
• Healthy volunteers: Not accepted

Summary

Cow's milk protein allergy (CMPA) is often evoked in infants, in particular in front of delayed symptoms such as rectal bleeding, atopic dermatitis, excessive crying, reflux, failure to thrive... But in case of non IgE-mediated CMPA, the only way to diagnose this allergy is to proceed to an elimination-reintroduction test over a period of 2 to 4 weeks, to improve symptoms first, and then provoke them. Even if the diagnosis is confirmed, we speculate that non IgE-mediated CMPA has a faster resolution than other CMPA. The first aim of this study is to estimate the prevalence of non IgE-mediated CMPA in a cohort of infants with delayed symptoms which could be relied to a CMPA. The second goal is evaluate the age of tolerance in non IgE-mediated CMPA with oral food challenge for milk ever 2 months after 4 months of age.

Conditions

• Food Allergy in Infants
• Proctocolitis
• Atopic Dermatitis
• Reflux, Gastroesophageal
• Tolerance

Interventions

Type	Name	Description
OTHER	oral food challenge 1	First oral food challenge after a short period of several weeks of avoidance of CMP to confirm diagnosis of CMPA
OTHER	oral food challenge 2	Second oral food challenge to test tolerance after 4 months of age if confirmed CMPA

Timeline

• Start date: 2014-05-01
• Primary completion: 2014-05-01
• Completion: 2017-12-01
• First posted: 2020-12-03
• Last updated: 2020-12-03

Locations

1 site across 1 country: France