NCT04649840

Estimation of Dynamics of Humoral and Cellular Immunity in COVID-19 Patients

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 274 (actual)
• Sponsor: Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus · Other Government
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of the project: to study the dynamics of the humoral and cellular immunity in patients after pneumonia caused by the SARS-CoV-2 virus at different time intervals, in order to predict the duration of immune protection

Detailed description

* to form study groups of patients (at least 60 patients in total) who have recovered from pneumonia of varying severity caused by the SARS-CoV-2 virus (at least 30 patients in each of the groups of patients who have had pneumonia in moderate and severe forms); * to investigate the parameters of cellular immunity (the content of antigen-specific T-cells to the main viral antigens - proteins S, N, M) in patients of different groups included in the trials, in dynamics 3, 6, 9 and 12 months after the COVID-19-associated pneumonia; * to investigate the indicators of humoral immunity (the content of IgG to the main viral antigens - proteins S, N, M) in patients of different groups included in the trials, in dynamics 3, 6, 9 and 12 months after the COVID-19-associated pneumonia.

Conditions

• Covid19

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Humoral and cellular immunity	Humoral (IgG) and cellular (antigen-specific cells) immunity

Timeline

• Start date: 2020-10-01
• Primary completion: 2021-12-09
• Completion: 2021-12-09
• First posted: 2020-12-02
• Last updated: 2021-12-10

Locations

1 site across 1 country: Belarus