Trials / Completed
CompletedNCT04649294
The Effect of High Dose Glucocorticoid Steroids on Myocardial Function
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 23 (actual)
- Sponsor
- Hillel Yaffe Medical Center · Other Government
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
Long term steroid exposure, as in Cushing's disease, causes myocardial dysfunction, hypertrophy and fibrosis in addition to causing obesity, hypertension and glucose intolerance. The aim of our study was to verify if short-term high-dose exogenous steroid therapy adversely effects the heart.
Detailed description
Patients eligible for high dose steroid therapy due to inflammatory diseases were offered to participate in this study. The minimal total intravenous dose was 375 mg prednisone, and the daily steroids were divided into 2-3 doses. To determine the steroids' effect on myocardial function the echocardiographic studies included estimation of global and segmental longitudinal strain. Each patient had a baseline echocardiographic study performed before high-dose steroid therapy was initiated and again immediately after it. A follow-up echo study was performed after completion of a 3-month low-dose steroid therapy period. The paired 2-tailed t-test was used to compare group means
Conditions
Timeline
- Start date
- 2017-06-01
- Primary completion
- 2018-06-01
- Completion
- 2018-12-20
- First posted
- 2020-12-02
- Last updated
- 2020-12-02
Locations
1 site across 1 country: Israel
Source: ClinicalTrials.gov record NCT04649294. Inclusion in this directory is not an endorsement.