NCT04647734

The Protective Potential of Exercise Training on the Cardiopulmonary Morbidity After COVID-19

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 28 (actual)
• Sponsor: Rigshospitalet, Denmark · Academic / Other
• Sex: All
• Age: 40 Years
• Healthy volunteers: Accepted

Summary

40 COVID-19 survivors that have been discharged from the hospital will be included in this investigator-blinded randomised study with a 12-week exercise intervention. Patients will be 1:1 block-randomised by sex to either a supervised high intensity interval-based exercise group or standard care (control group).

Detailed description

40 patients will be recruited and undergo baseline testing, including examination, biochemistry, ECG, DXA, OGTT, Pulmonary function, VO2max, RM, plasma volume, AX3, CGM, echocardiography, cardiac MRI. After baseline testing, participants will be randomly allocated into one group receiving standard of care (control group) or a group performing supervised high-intensity interval training three times a week over a period of 12 weeks. The randomization procedure involves a computer-generated block randomization schedule in a ratio of 1:1 stratified by sex by an independent person. Following the 12-week intervention period, both groups will complete a series of follow-up tests (as baseline testing). A 1-year follow-up experimental day is also planned in order to evaluate fitness, cardiac and pulmonary structure and function.

Conditions

• COVID-19, SARS-CoV2

Interventions

Type	Name	Description
BEHAVIORAL	High intensity interval training	12 weeks of high intensity interval training on exercise bike for 38 minutes 3 times a week
BEHAVIORAL	Standard care	standard care after discharge from hospital (control group)

Timeline

• Start date: 2021-02-01
• Primary completion: 2022-02-01
• Completion: 2022-02-10
• First posted: 2020-12-01
• Last updated: 2022-06-08

Locations

1 site across 1 country: Denmark