NCT04642716

Evaluation of Free Aminoacids in Saliva as A Diagnostic Biomarker of Periodontal Disease

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Istanbul Medipol University Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Amino acids (AAs) are organic molecules that are associated with inflammation and innate immunity diseases with critical roles in the cell repair and protection process. Our aim was to identify the free amino acids in saliva of a group of periodontitis patients and healthy individuals and additionally to assess their levels in different periodontal disease types and compare it to the healthy individuals.

Detailed description

The study consisted of three groups: healthy individuals (control(C); n=20), Stage III Grade B generalized periodontitis (GP-B; n=20), and Stage III Grade C generalized periodontitis (GP-C; n=20). Clinical periodontal parameters (plaque index (PI), gingival index (GI), probing depth (PPD), gingival recession (GR), clinical attachment level (CAL) and bleeding on probing (BOP)) were measured. The amino acid analysis in saliva was accomplished by liquid chromatography-mass spectrometry (LC MS/MS) as mean concentration.

Conditions

• Periodontitis
• Diagnoses Disease

Interventions

Type	Name	Description
OTHER	Saliva collection of patients and salivary free amino acids analysis

Timeline

• Start date: 2015-04-20
• Primary completion: 2017-04-15
• Completion: 2017-08-03
• First posted: 2020-11-24
• Last updated: 2020-11-24

Locations

1 site across 1 country: Turkey (Türkiye)