NCT04641598

Menstrual Phase Endometrial Scratch in IUI Cycles

The Effect of Menstrual Phase Endometrial Scratch on Intrauterine Insemination Cycle Outcomes and Participant Acceptability

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 57 (actual)
• Sponsor: Carilion Clinic · Academic / Other
• Sex: Female
• Age: 18 Years – 37 Years
• Healthy volunteers: Accepted

Summary

Patients undergoing treatment with intrauterine insemination (IUI) will be randomized to receive an endometrial scratch or sham procedure during the menstrual phase of the treatment cycle.

Detailed description

Infertility is a common issue faced by many couples throughout the United States. There are multiple fertility treatment options, including in vitro fertilization (IVF) and intrauterine insemination (IUI). Additionally, methods such as endometrial scratch (a modified endometrial biopsy) have been postulated to increase success rate. This prospective, randomized control trial will assess whether performing an endometrial scratch improves cycle outcomes and decreases time to pregnancy following IUI. Each patient will be randomly assigned to receive either an endometrial scratch or undergo a "sham" procedure (speculum insertion but no scratch) during the menstrual phase of the IUI cycle.

Conditions

• Fertility Disorders
• Fertility Issues

Interventions

Type	Name	Description
PROCEDURE	Endometrial Scratch	An endometrial biopsy pipelle will be used to create endometrial injury in the form of a "scratch".
PROCEDURE	Sham procedure	Motions of performing an endometrial scratch will be performed including speculum placement and cervix cleansing, however, placement of the tenaculum and the endometrial scratch will not be performed.

Timeline

• Start date: 2018-08-31
• Primary completion: 2021-08-02
• Completion: 2021-08-02
• First posted: 2020-11-24
• Last updated: 2021-08-06

Locations

1 site across 1 country: United States