NCT04637217

Retinal Neurodegenerative and Vascular Changes in Diabetic Patients

Retinal Neurodegenerative and Vascular Changes in Diabetic Patients: an OCT-based Comparative Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 97 (actual)
• Sponsor: Iuliu Hatieganu University of Medicine and Pharmacy · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

Using Optical Coherence Tomography and ImageJ software the investigators will analyze retinal and choroidal vascular changes and their impact on retinal layers among patients with diabetes without retinopathy and patients with diabetes and retinopathy.

Detailed description

Relieving the burden of diabetic retinopathy treatment require a prompt and non-invasive assessment of diabetic patients before the occurence of diabetic retinopathy. Since OCT is capable of imaging retina with such a high precision, retinal changes occuring before any clinical signs of retinopathy, such as microaneurysm or haemorrhages, can now be assessed. In the present study the investigators are analyzing the connection between retinal arteries and veins regarding lumen diameter, vessel wall thickness and their correlation with retinal nerve fiber layer and ganglion cell layer thickness. Moreover, using binarization of the choroid the investigators will assess its relationship with outer retina layers, such as retinal pigment epithelium and photoreceptors.

Conditions

• Diabetic Retinopathy
• Neurodegeneration

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Optical Coherence Tomography	Spectral Domain Optical Coherence Tomography(SD-OCT) examination will be performed for every patient: posterior pole scan, EDI-OCT(enhanced depth imaging-OCT) and peripapillary RNFL(retinal nerve fiber layer)

Timeline

• Start date: 2018-07-01
• Primary completion: 2019-07-01
• Completion: 2019-07-01
• First posted: 2020-11-19
• Last updated: 2020-11-19

Locations

1 site across 1 country: Romania