NCT04636255

Physical Capacity in Hodgkin Lymphoma Survivors

Physical Capacity Evaluation and Effects of ExerciseTraining on Hodgkin Lymphoma Survivors

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: University of Sao Paulo General Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The study aims to investigate if physical capacity obtained in the cardiopulmonary exercise test can predict cardiovascular alterations in Hodgkin Lymphoma (HL) Survivors. In addition, to study the effects of exercise training on physical capacity and cardiovascular responses in these patients.

Detailed description

Hodgkin Lymphoma (HL) is a hematological neoplasia that mainly affects young people. Anthracycline-based chemotherapy, followed or not by mediastinal radiotherapy, substantially improves prognosis in this set of patients. Observational studies have shown that cardiovascular disease is the most non oncologic cause of death in this population. Coronary artery disease (CAD) affects 26% of survivors after 10 years of absence of HL . However, the early intervention and the assessment to predict the cardiovascular risk remain little known. In this study, the investigators will test the hypothesis that physical capacity can predict the cardiovascular alterations in HL Survivors. In addition, exercise training improves physical capacity and heart rate responses in this set of patients.

Conditions

• Hodgkin Lymphoma, Adult
• Cardiovascular Diseases
• Radiation Effect
• Chemotherapy Effect

Interventions

Type	Name	Description
PROCEDURE	Physical Characteristics	Body Weight, Height
DIAGNOSTIC_TEST	Assessment of Heart rate variability	Holter 24h
DIAGNOSTIC_TEST	Blood Pressure and Cardiac Autonomic Control	Non-invasive photoplethysmography (Finometer® PRO) monitored by the electrocardiogram and respiratory frequency by a piezoelectric chest strap.
DIAGNOSTIC_TEST	Evaluation of Baroreflex Control	The magnitude and latency of the baroreflex control of the heart rate will be assessed by bivariate analysis using the autoregressive method.
DIAGNOSTIC_TEST	Cardiac Function and Structure	Echocardiogram
DIAGNOSTIC_TEST	Assessment of Coronary Anatomy and Calcium Score	Angiotomography
DIAGNOSTIC_TEST	Blood Assessments	Serum and Plasma will be extracted by centrifugation. NT-pro BNP (Roche™) and c-TnI (imunoassay Elecys 2010).
DIAGNOSTIC_TEST	Physical Capacity	Cardiopulmonary Exercise Test.
PROCEDURE	Physical Training	Aerobic exercise: 48 sessions of 60 minutes: 5 minutes of warm-up, 40 minutes of exercise. Resistance exercise: 10 minutes of exercise and 5 minutes of recovery.

Timeline

• Start date: 2017-10-21
• Primary completion: 2022-10-21
• Completion: 2023-10-21
• First posted: 2020-11-19
• Last updated: 2023-05-10

Locations

1 site across 1 country: Brazil